David M Pollock Selected Research

Endothelin-1 (Endothelin 1)

1/2022	Endothelin receptor blockade blunts the pressor response to acute stress in men and women with obesity.
1/2021	Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice.
1/2019	Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse.
1/2019	Afferent arteriole responsiveness to endothelin receptor activation: does sex matter?
1/2018	Endothelin type A receptors mediate pain in a mouse model of sickle cell disease.
10/2017	Renal denervation attenuates hypertension but not salt sensitivity in ETB receptor-deficient rats.
1/2017	Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney.
1/2017	The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.
12/2016	Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes.
1/2016	Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.

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David M Pollock Research Topics

Disease

72	Hypertension (High Blood Pressure) 01/2022 - 02/2002
13	Proteinuria 01/2021 - 03/2006
13	Inflammation (Inflammations) 01/2020 - 01/2007
12	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 09/2002
12	Albuminuria 11/2019 - 08/2004
9	Sickle Cell Anemia (Hemoglobin S Disease) 07/2022 - 01/2016
5	Obesity 01/2022 - 08/2004
5	Diabetic Nephropathies (Diabetic Nephropathy) 10/2013 - 01/2007
5	Stroke (Strokes) 06/2011 - 12/2005
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2016 - 01/2005
4	Hyperglycemia 07/2011 - 04/2004
4	Ischemic Stroke 01/2008 - 03/2006
4	Brain Ischemia (Cerebral Ischemia) 01/2008 - 12/2005
4	Cerebral Infarction 10/2007 - 12/2005
3	Pulmonary Arterial Hypertension 01/2018 - 11/2012
3	Kidney Diseases (Kidney Disease) 01/2018 - 06/2013
3	Fibrosis (Cirrhosis) 08/2017 - 01/2013
3	Infarction (Infarctions) 10/2007 - 03/2006
2	Overweight 01/2022 - 01/2022
2	Essential Hypertension 11/2021 - 06/2011
2	Reperfusion Injury 05/2014 - 08/2010
2	Chronic Renal Insufficiency 10/2013 - 01/2011
2	Ganglion Cysts (Ganglion) 08/2013 - 09/2007
2	Hypertrophy 01/2013 - 01/2007
2	Edema (Dropsy) 11/2012 - 03/2006
2	Insulin Resistance 10/2007 - 10/2005
2	Diabetes Complications 08/2007 - 11/2005
2	Type 2 Diabetes Mellitus (MODY) 02/2006 - 08/2004
1	Iron Overload 07/2022
1	Anemia 07/2022
1	Weight Loss (Weight Reduction) 01/2022

Drug/Important Bio-Agent (IBA)

40	SaltsIBA 01/2022 - 02/2002
27	Endothelins (Endothelin)IBA 01/2022 - 07/2002
26	Endothelin-1 (Endothelin 1)IBA 01/2022 - 05/2002
14	Angiotensin IIIBA 12/2011 - 02/2002
8	Desoxycorticosterone Acetate (DOCA)FDA Link 03/2016 - 02/2002
8	Superoxides (Superoxide)IBA 02/2007 - 03/2003
7	SodiumIBA 01/2022 - 01/2007
7	Nitric Oxide Synthase (NO Synthase)IBA 11/2013 - 02/2002
7	AngiotensinsIBA 10/2010 - 03/2003
7	Proteins (Proteins, Gene)FDA Link 01/2010 - 02/2002
5	ambrisentan FDA Link 07/2022 - 11/2012
5	AlbuminsIBA 12/2016 - 11/2010
5	Antihypertensive Agents (Antihypertensives)IBA 11/2014 - 05/2004
5	AtrasentanIBA 11/2014 - 01/2007
4	Endothelin A ReceptorIBA 07/2022 - 11/2004
4	Bosentan (Tracleer)FDA Link 01/2022 - 11/2007
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 03/2003
4	MineralocorticoidsIBA 03/2016 - 02/2006
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 11/2004
4	Streptozocin (Streptozotocin)FDA Link 01/2013 - 01/2005
4	Desoxycorticosterone (Deoxycorticosterone)IBA 10/2010 - 09/2002
4	Acetates (Acetic Acid Esters)FDA Link 10/2010 - 09/2002
3	Endothelin Receptors (Endothelin Receptor)IBA 01/2022 - 11/2007
3	KininsIBA 01/2020 - 06/2003
3	butyl phosphorotrithioate (DEF)IBA 01/2018 - 03/2015
3	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2016 - 05/2004
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 07/2011 - 12/2007
3	Spironolactone (Aldactone)FDA LinkGeneric 06/2011 - 05/2007
3	Peptides (Polypeptides)IBA 11/2010 - 09/2002
3	Endothelin B ReceptorIBA 04/2009 - 08/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 03/2006
3	Insulin (Novolin)FDA Link 10/2007 - 01/2005
3	Enalapril FDA LinkGeneric 02/2007 - 06/2003
3	cytochrome P-450 CYP2C subfamilyIBA 03/2006 - 10/2003
3	Epoxide HydrolasesIBA 12/2005 - 05/2004
3	EnzymesIBA 04/2004 - 03/2003
2	IronIBA 07/2022 - 08/2017
2	hemoglobin AAIBA 01/2021 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2006
2	ElectrolytesIBA 01/2020 - 05/2015
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2013
2	Low Density Lipoprotein Receptor-Related Protein-2IBA 01/2019 - 08/2017
2	Free RadicalsIBA 12/2016 - 03/2003
2	Hemoglobins (Hemoglobin)IBA 01/2016 - 03/2006
2	Carboxylic AcidsIBA 11/2014 - 07/2011
2	pyrrolidineIBA 11/2014 - 07/2011
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 11/2013 - 10/2010
2	sitaxsentanIBA 10/2013 - 11/2007
2	Endothelin Receptor AntagonistsIBA 10/2013 - 11/2012
2	Adrenergic Agents (Adrenergic Drugs)IBA 08/2013 - 12/2006
2	CollagenIBA 01/2013 - 12/2007
2	Protein Isoforms (Isoforms)IBA 01/2013 - 01/2011
2	AcidsIBA 07/2011 - 10/2005
2	Matrix Metalloproteinases (MMPs)IBA 07/2011 - 02/2006
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 06/2011 - 10/2007
2	Pharmaceutical PreparationsIBA 01/2011 - 03/2003
2	ReninIBA 10/2010 - 03/2005
2	Dietary PotassiumIBA 01/2008 - 01/2007
2	Etanercept (Enbrel)FDA Link 01/2008 - 03/2006
2	FructoseIBA 10/2007 - 10/2005
2	Mineralocorticoid Receptor AntagonistsIBA 10/2007 - 05/2007
2	tempolIBA 02/2007 - 11/2004
2	salicylhydroxamic acid (SHAM)IBA 01/2007 - 01/2005
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 08/2004 - 03/2003
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2003 - 06/2003
1	Heme Oxygenase-1IBA 07/2022
1	Dietary SodiumIBA 11/2021

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2008
2	Denervation 10/2017 - 08/2013